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The Perfect Game is about a group of boys from Monterrey, Mexico, who became the first non-U.S. team to win the Little League World Series in 1957. It is based on a true story about 9 kids who go to America and get criticized until they beat the very best American little league baseball team in 1957, and have the only perfect game in championship history. Digital work to recreate the separate looks for the United States and Monterrey in 1957 was done by Post Logic Studios.

When Cesar Faz (Clifton Collins, Jr.) is laid off from his janitorial job with the St. Louis Cardinals he moves back to Monterrey. There he meets local children being led by Padre Esteban (Cheech Marin) enjoying baseball. He takes pitcher Angel Macias (Jake T. Austin) under his wing and brags about his own pitching skills and how he used to coach the Cardinals. Angel convinces Cesar to help recruit and coach Monterrey's first-ever Little League team. With Cesar's skills and Padre Esteban's support, the boys hone themselves into a competitive team worthy of international competition.

When the team arrives in the United States, they are met with racism, a language barrier and visa troubles. Though the underdogs, the team scores a series of victories that endear them to the media, and new fans. They befriend a sports reporter, Frankie (Emilie de Ravin) and the groundskeeper, Cool Papa Bell (Lou Gossett, Jr.), who then assist the boys in reaching the final game.