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Splice is a 2010 science fiction film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley, who portray two young scientists and lovers who begin involving human DNA in their splicing of animal genes.

Superstar genetic engineers Clive (Brody) and Elsa (Polley) achieve fame by successfully splicing together the DNA of different animals, to create incredible new hybrids. Now they want to use human DNA in a hybrid that could revolutionize science and medicine. But when the pharmaceutical company that funds their research forbids it, Clive and Elsa secretly conduct their own experiments in the pursuit of even greater scientific discovery. They secretly blend human DNA with their creations, ignoring their society's ethical and legal boundaries. The scientists name their creature "Dren", a creature that exhibits uncommon intelligence and an array of unexpected physical developments. And though, at first, Dren exceeds their wildest dreams, she begins to grow and learn at an accelerated rate—and threatens to become their worst nightmare. The two must come to terms with their decision as their creature quickly develops into a deadly, winged humanoid-chimera.